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Gene RET
Variant G446R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET G446R lies within the extracellular domain of the Ret protein (UniProt.org). G446R has been identified in sequencing studies (PMID: 24728327), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET G446R

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Transcript NM_020975.6
gDNA chr10:g.43111279G>C
cDNA c.1336G>C
Protein p.G446R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43113570G>A c.1336G>A p.G446R RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_020630 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_020975 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43113570G>A c.1336G>A p.G446R RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43111279G>C c.1336G>C p.G446R RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries