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Gene BRAF
Variant I463T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF I463T lies within the protein kinase domain of the Braf protein (UniProt.org). I463T is predicted to lead to Braf activation based on structural modeling (PMID: 28829677), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF I463X BRAF I463T

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Transcript NM_004333.6
gDNA chr7:g.140781620A>G
cDNA c.1388T>C
Protein p.I463T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420769.1 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140776954A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
NM_004333 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781620A>G c.1388T>C p.I463T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References