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Gene ALK
Variant D1203fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ALK D1203fs results in a change in the amino acid sequence of the Alk protein beginning at aa 1203 of 1620, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the ATP binding site (UniProt.org), D1203fs is predicted to lead to a loss of Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK inact mut ALK D1203fs

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Transcript NM_004304.5
gDNA chr2:g.(29220744_29220745)
cDNA c.(3607_3606)
Protein p.D1203fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.(29220744_29220745) c.(3607_3606) p.D1203fs RefSeq GRCh38/hg38
NM_004304.5 chr2:g.(29220744_29220745) c.(3607_3606) p.D1203fs RefSeq GRCh38/hg38
NM_004304.4 chr2:g.(29220744_29220745) c.(3607_3606) p.D1203fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK D1203fs loss of function - predicted