ALK G1123S
Gene Variant Detail

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Gene ALK
Variant G1123S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK G1123S lies within the protein kinase domain of the Alk protein (UniProt.org). G1123S has been demonstrated to confer drug resistance in culture (PMID: 26134233, PMID: 21948233), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK G1123S

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Transcript NM_004304.5
gDNA chr2:g.29222600C>T
cDNA c.3367G>A
Protein p.G1123S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29222600C>T c.3367G>A p.G1123S RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222600C>T c.3367G>A p.G1123S RefSeq GRCh38/hg38
NM_004304 chr2:g.29222600C>T c.3367G>A p.G1123S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References