RET T742M
Gene Variant Detail

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Gene RET
Variant T742M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET T742M lies within the protein kinase domain of the Ret protein (UniProt.org). T742M has been identified in the scientific literature (PMID: 31712133, PMID: 32284345), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET T742M

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Transcript NM_020975.6
gDNA chr10:g.43116672C>T
cDNA c.2225C>T
Protein p.T742M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_020630 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43116672C>T c.2225C>T p.T742M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References