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Gene | ALK |
Variant | A585T |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | ALK A585T lies within MAM domain 2 of the Alk protein (UniProt.org). A585T has not been biochemically characterized, but results in similar cell proliferation and viability levels to wild-type Alk in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Alk protein function. |
Associated Drug Resistance | |
Category Variants Paths |
ALK mutant ALK A585T |
Transcript | NM_004304.5 |
gDNA | chr2:g.29296952C>T |
cDNA | c.1753G>A |
Protein | p.A585T |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |