Gene Variant Detail

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Gene BRAF
Variant A762V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF A762V does not lie within any known functional domains of the Braf protein (UniProt.org). A762V has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF A762V

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Transcript NM_004333.6
gDNA chr7:g.140734613G>A
cDNA c.2285C>T
Protein p.A762V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.6 chr7:g.140734613G>A c.2285C>T p.A762V RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140734613G>A c.2285C>T p.A762V RefSeq GRCh38/hg38
NM_004333 chr7:g.140734613G>A c.2285C>T p.A762V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References