Gene Variant Detail

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Gene BRAF
Variant E228V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF E228V does not lie within any known functional domains of the Braf protein (UniProt.org). E228V has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF E228V

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Transcript NM_004333.6
gDNA chr7:g.140807988T>A
cDNA c.683A>T
Protein p.E228V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017012558.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
XM_005250045 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_004333 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
XM_017012559 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
XM_017012558 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140807997T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140807988T>A c.683A>T p.E228V RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References