Gene Variant Detail

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Gene BRAF
Variant F259L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF F259L lies within the phorbol-ester/DAG-type zinc finger domain of the Braf protein (UniProt.org). F259L has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF F259L

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Transcript NM_004333.6
gDNA chr7:g.140801497A>G
cDNA c.775T>C
Protein p.F259L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.2 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_005250045 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012558 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140801506A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_004333 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012559 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References