Gene Variant Detail

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Gene BRAF
Variant F259L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF F259L lies within the phorbol-ester/DAG-type zinc finger domain of the Braf protein (UniProt.org). F259L has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF F259L

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Transcript NM_004333.6
gDNA chr7:g.140801497A>G
cDNA c.775T>C
Protein p.F259L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012559 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_004333 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012558 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140801506A>G c.775T>C p.F259L RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140801497A>G c.775T>C p.F259L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF F259L no effect - predicted