Gene Variant Detail

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Gene BRAF
Variant G421V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF G421V does not lie within any known functional domains of the Braf protein (UniProt.org). G421V has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G421V

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Transcript NM_004333.6
gDNA chr7:g.140783073C>A
cDNA c.1262G>T
Protein p.G421V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.6 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
NM_004333 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140781644C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38
XM_005250045 chr7:g.140783073C>A c.1262G>T p.G421V RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries