Gene Variant Detail

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Gene BRAF
Variant L711F
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF L711F lies within the protein kinase domain of the Braf protein (UniProt.org). L711F has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF L711F

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Transcript NM_004333.6
gDNA chr7:g.140734767G>A
cDNA c.2131C>T
Protein p.L711F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140734767G>A c.2131C>T p.L711F RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140734767G>A c.2131C>T p.L711F RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140734767G>A c.2131C>T p.L711F RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140734767G>A c.2131C>T p.L711F RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140734767G>A c.2131C>T p.L711F RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140734663_140734665delCTAinsTTT c.2131_2133delCTAinsTTT p.L711F RefSeq GRCh38/hg38
XM_005250045 chr7:g.140734767G>A c.2131C>T p.L711F RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140734699C>A c.2133G>T p.L711F RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries