Gene Variant Detail

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Gene BRAF
Variant P407L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF P407L does not lie within any known functional domains of the Braf protein (UniProt.org). P407L has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF P407L

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Transcript NM_004333.6
gDNA chr7:g.140783115G>A
cDNA c.1220C>T
Protein p.P407L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38
NM_004333 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38
XM_005250045 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140783115G>A c.1220C>T p.P407L RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries