Gene Variant Detail

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Gene BRAF
Variant R271H
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF R271H lies within the phorbol-ester/DAG-type zinc finger domain of the Braf protein (UniProt.org). R271H has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF R271H

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Transcript NM_004333.6
gDNA chr7:g.140801460C>T
cDNA c.812G>A
Protein p.R271H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_047420770.1 chr7:g.140777079_140777080delGAinsAT c.812_813delGAinsAT p.R271H RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_005250045 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_017012558 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_017012559 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140801460C>T c.812G>A p.R271H RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References