Gene Variant Detail

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Gene BRAF
Variant R389C
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF R389C does not lie within any known functional domains of the Braf protein (UniProt.org). R389C has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF R389C

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Transcript NM_004333.6
gDNA chr7:g.140787560G>A
cDNA c.1165C>T
Protein p.R389C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001374244.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_004333 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_005250045 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140783057_140783059delAGGinsTGT c.1165_1167delAGGinsTGT p.R389C RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_017012559 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
XM_017012558 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140787560G>A c.1165C>T p.R389C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References