Gene Variant Detail

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Gene BRAF
Variant R509G
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF R509G lies within the protein kinase domain of the Braf protein (UniProt.org). R509G has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF R509G

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Transcript NM_004333.6
gDNA chr7:g.140777081G>C
cDNA c.1525C>G
Protein p.R509G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378467.1 chr7:g.140777992T>C c.1525A>G p.R509G RefSeq GRCh38/hg38
NM_004333 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38
XM_005250045 chr7:g.140777081G>C c.1525C>G p.R509G RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References