Gene Variant Detail

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Gene BRAF
Variant R671Q
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF R671Q lies within the protein kinase domain of the Braf protein (UniProt.org). R671Q has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF R671Q

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Transcript NM_004333.6
gDNA chr7:g.140739927C>T
cDNA c.2012G>A
Protein p.R671Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140739927C>T c.2012G>A p.R671Q RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140739927C>T c.2012G>A p.R671Q RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140739927C>T c.2012G>A p.R671Q RefSeq GRCh38/hg38
NM_004333 chr7:g.140739927C>T c.2012G>A p.R671Q RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140739927C>T c.2012G>A p.R671Q RefSeq GRCh38/hg38
XM_005250045 chr7:g.140739927C>T c.2012G>A p.R671Q RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140739927C>T c.2012G>A p.R671Q RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140739927C>T c.2012G>A p.R671Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF R671Q no effect - predicted