Gene Variant Detail

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Gene BRAF
Variant R719S
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF R719S does not lie with any known functional domains of the Braf protein (UniProt.org). R719S has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF R719S

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Transcript NM_004333.6
gDNA chr7:g.140734743G>T
cDNA c.2155C>A
Protein p.R719S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140734743G>T c.2155C>A p.R719S RefSeq GRCh38/hg38
NM_004333 chr7:g.140734743G>T c.2155C>A p.R719S RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140734743G>T c.2155C>A p.R719S RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140734743G>T c.2155C>A p.R719S RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140734743G>T c.2155C>A p.R719S RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140734743G>T c.2155C>A p.R719S RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries