Gene Variant Detail

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Gene BRAF
Variant S419Y
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF S419Y does not lie within any known functional domains of the Braf protein (UniProt.org). S419Y has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF S419Y

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Transcript NM_004333.6
gDNA chr7:g.140783079G>T
cDNA c.1256C>A
Protein p.S419Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
XM_047420770.1 chr7:g.140749308_140749309delCAinsAT c.1256_1257delCAinsAT p.S419Y RefSeq GRCh38/hg38
XM_017012558 chr7:g.140785730_140785731delCTinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38
XM_017012559 chr7:g.140785730_140785731delCTinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140783043G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140785730_140785731delAGinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140785730_140785731delAGinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140785730_140785731delAGinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140785730_140785731delAGinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140785730_140785731delAGinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
XM_005250045 chr7:g.140783079G>T c.1256C>A p.S419Y RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140785730_140785731delAGinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140785730_140785731delAGinsTA c.1255_1256delAGinsTA p.S419Y RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References