Gene Variant Detail

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Gene BRAF
Variant V639I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF V639I lies within the protein kinase domain of the Braf protein (UniProt.org). V639I has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF V639I

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Transcript NM_004333.6
gDNA chr7:g.140749364C>T
cDNA c.1915G>A
Protein p.V639I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140749364C>T c.1915G>A p.V639I RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140749364C>T c.1915G>A p.V639I RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140749364C>T c.1915G>A p.V639I RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140749364C>T c.1915G>A p.V639I RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140749364C>T c.1915G>A p.V639I RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140749364C>T c.1915G>A p.V639I RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140749364C>T c.1915G>A p.V639I RefSeq GRCh38/hg38
NM_004333 chr7:g.140749364C>T c.1915G>A p.V639I RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries