Gene Variant Detail

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Gene BRAF
Variant V681I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF V681I lies within the protein kinase domain of the Braf protein (UniProt.org). V681I has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF V681I

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Transcript NM_004333.6
gDNA chr7:g.140739898C>T
cDNA c.2041G>A
Protein p.V681I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140739898C>T c.2041G>A p.V681I RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140739898C>T c.2041G>A p.V681I RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140739898C>T c.2041G>A p.V681I RefSeq GRCh38/hg38
NM_004333 chr7:g.140739898C>T c.2041G>A p.V681I RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140739898C>T c.2041G>A p.V681I RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140739898C>T c.2041G>A p.V681I RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140739898C>T c.2041G>A p.V681I RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140739898C>T c.2041G>A p.V681I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
BRAF V681I no effect - predicted