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Gene RET
Variant D631_R635delinsG
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_R635delinsG results in a deletion of five amino acids in the extracellular domain of the Ret protein from amino acids 631 to 635, combined with the insertion of one glycine (G) at the same site (UniProt.org). D631_R635delinsG has been identified in the scientific literature (PMID: 29657135), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631_R635delinsG

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Transcript NM_020975.6
gDNA chr10:g.43114492_43114503del12
cDNA c.1892_1903del12
Protein p.D631_R635delinsG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.5 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020975 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020630 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
RET D631_R635delinsG unknown
RET L629P RET D631_R635delinsG RET V637R