RET D631_R635delinsG
Gene Variant Detail

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Gene RET
Variant D631_R635delinsG
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_R635delinsG results in a deletion of five amino acids in the extracellular domain of the Ret protein from amino acids 631 to 635, combined with the insertion of a glycine (G) at the same site (UniProt.org). D631_R635delinsG has been identified in the scientific literature (PMID: 29657135), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631_R635delinsG

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Transcript NM_020975.6
gDNA chr10:g.43114492_43114503del12
cDNA c.1892_1903del12
Protein p.D631_R635delinsG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020975 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114492_43114503del12 c.1892_1903del12 p.D631_R635delinsG RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References