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Gene | RET |
Variant | L629P |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | RET L629P lies within the extracellular domain of the Ret protein (UniProt.org). L629P has been identified in the scientific literature (PMID: 29657135), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024). |
Associated Drug Resistance | |
Category Variants Paths |
RET mutant RET L629P |
Transcript | NM_020975.6 |
gDNA | chr10:g.43114486T>C |
cDNA | c.1886T>C |
Protein | p.L629P |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_020975.5 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_020975.6 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_020975 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_001406744.1 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_001406759.1 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_001406760.1 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_020630.7 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_001406743.1 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_020630 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
NM_020630.5 | chr10:g.43114486T>C | c.1886T>C | p.L629P | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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