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Gene RET
Variant V804E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET V804E lies within the protein kinase domain of the Ret protein (UniProt.org). V804E has been demonstrated to confer drug resistance in the context of a RET fusion in culture (PMID: 29657135), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET V804X RET V804E

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Transcript NM_020975.6
gDNA chr10:g.43119549T>A
cDNA c.2411T>A
Protein p.V804E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020975 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020630 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET V804E Advanced Solid Tumor predicted - sensitive APS03118 Preclinical - Biochemical Actionable In a preclinical study, APS03118 inhibited the enzymatic activity of RET V804E in an in vitro assay (J Clin Oncol 40, no. 16_suppl (June 1, 2022)). detail...
RET V804E Advanced Solid Tumor predicted - sensitive TY-1091 Preclinical - Biochemical Actionable In a preclinical study, TY-1091 inhibited activity in a cell line expressing RET V804E in culture (Cancer Res (2023) 83 (7_Supplement): 3419). detail...