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Gene RET
Variant V804E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET V804E lies within the protein kinase domain of the Ret protein (UniProt.org). V804E has been demonstrated to confer drug resistance in the context of a RET fusion in culture (PMID: 29657135), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET V804X RET V804E

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Transcript NM_020975.6
gDNA chr10:g.43119549T>A
cDNA c.2411T>A
Protein p.V804E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020630 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020975 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119549T>A c.2411T>A p.V804E RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries