Gene Variant Detail

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Gene MAP2K1
Variant S222A
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions MAP2K1 S222A lies within the protein kinase domain of the Map2k1 protein (UniProt.org). S222A results in similar cell proliferation and viability levels as wild-type Map2k1 (PMID: 29533785), and therefore, is predicted to have no effect on Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 S222A

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Transcript NM_002755.4
gDNA chr15:g.66481850T>G
cDNA c.664T>G
Protein p.S222A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.4 chr15:g.66481850T>G c.664T>G p.S222A RefSeq GRCh38/hg38
NM_002755 chr15:g.66481850T>G c.664T>G p.S222A RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66481850T>G c.664T>G p.S222A RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66485038_66485039delAGinsGC c.664_665delAGinsGC p.S222A RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66485026T>G c.664T>G p.S222A RefSeq GRCh38/hg38
XM_017022411 chr15:g.66485038_66485039delAGinsGC c.664_665delAGinsGC p.S222A RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66485026T>G c.664T>G p.S222A RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66485038_66485039delAGinsGC c.664_665delAGinsGC p.S222A RefSeq GRCh38/hg38
XM_011521783 chr15:g.66485026T>G c.664T>G p.S222A RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries