Gene Variant Detail

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Gene BRAF
Variant G258V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G258V lies within the phorbol-ester/DAG-type zinc finger domain of the Braf protein (UniProt.org). G258V results in increased transformation ability compared to wild-type Braf in one of two different cell lines in culture (PMID: 29533785), but has not been fully biochemically characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G258V

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Transcript NM_004333.6
gDNA chr7:g.140801499C>A
cDNA c.773G>T
Protein p.G258V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_017012558 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_017012559 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_005250045 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_004333 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140801499C>A c.773G>T p.G258V RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries