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Gene | BRAF |
Variant | G615R |
Impact List | missense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | BRAF G615R lies within the protein kinase domain of the Braf protein (UniProt.org). G615R has not been biochemically characterized, but demonstrates decreased transformation ability in cell culture (PMID: 29533785), and therefore, is predicted to lead to a loss of Braf protein function. |
Associated Drug Resistance | |
Category Variants Paths |
BRAF mutant BRAF inact mut BRAF G615R |
Transcript | NM_004333.6 |
gDNA | chr7:g.140753292C>T |
cDNA | c.1843G>A |
Protein | p.G615R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001354609.2 | chr7:g.140753292C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
NM_001354609.1 | chr7:g.140753292C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
NM_004333 | chr7:g.140753292C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
NM_001378474.1 | chr7:g.140753292C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
NM_004333.6 | chr7:g.140753292C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
NM_001378468.1 | chr7:g.140753292C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
NM_004333.5 | chr7:g.140753292C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
NM_001378471.1 | chr7:g.140749325C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
XM_005250045 | chr7:g.140753292C>T | c.1843G>A | p.G615R | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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