Gene Variant Detail

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Gene BRAF
Variant G69S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G69S does not lie within any known functional domains of the Braf protein (UniProt.org). G69S results in increased transformation ability compared to wild-type Braf in one of two different cell lines in culture (PMID: 29533785), but has not been fully biochemically characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G69S

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Transcript NM_004333.6
gDNA chr7:g.140850146C>T
cDNA c.205G>A
Protein p.G69S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001374258.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_004333 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_017012559 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_005250045 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38
XM_017012558 chr7:g.140850146C>T c.205G>A p.G69S RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries