Gene Variant Detail

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Gene BRAF
Variant H725Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF H725Y does not lie within any known functional domains of the Braf protein (UniProt.org). H725Y results in Erk1/2 phosphorylation level comparable to wild-type Braf in culture (PMID: 35385748), but demonstrates increased transforming ability in one of two different cell lines in culture (PMID: 29533785), and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF H725Y

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Transcript NM_004333.6
gDNA chr7:g.140734725G>A
cDNA c.2173C>T
Protein p.H725Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140734725G>A c.2173C>T p.H725Y RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140734725G>A c.2173C>T p.H725Y RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140734725G>A c.2173C>T p.H725Y RefSeq GRCh38/hg38
NM_004333 chr7:g.140734725G>A c.2173C>T p.H725Y RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140734725G>A c.2173C>T p.H725Y RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140734725G>A c.2173C>T p.H725Y RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries