Gene Variant Detail

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Gene BRAF
Variant K499N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF K499N lies within the protein kinase domain of the Braf protein (UniProt.org). K449N results in increased transformation ability compared to wild-type Braf in one of two different cell lines in culture (PMID: 29533785), but has not been fully biochemically characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF K499N

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Transcript NM_004333.6
gDNA chr7:g.140778011T>G
cDNA c.1497A>C
Protein p.K499N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_004333 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
XM_005250045 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
BRAF K499N unknown