Gene Variant Detail

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Gene BRAF
Variant K499N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF K499N lies within the protein kinase domain of the Braf protein (UniProt.org). K449N results in increased transformation ability compared to wild-type Braf in one of two different cell lines in culture (PMID: 29533785), but has not been fully biochemically characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF K499N

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Transcript NM_004333.6
gDNA chr7:g.140778011T>G
cDNA c.1497A>C
Protein p.K499N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
XM_005250045 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_004333 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140778011T>G c.1497A>C p.K499N RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References