Gene Variant Detail

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Gene BRAF
Variant N581K
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions BRAF N581K lies within the protein kinase domain of the Braf protein (UniProt.org). N581K has not been biochemically characterized, but demonstrates decreased transformation ability in cell culture (PMID: 29533785), and therefore, is predicted to lead to a loss of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF inact mut BRAF N581K

BRAF mutant BRAF N581X BRAF N581K

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Transcript NM_004333.6
gDNA chr7:g.140753392A>C
cDNA c.1743T>G
Protein p.N581K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753392A>C c.1743T>G p.N581K RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753392A>C c.1743T>G p.N581K RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753392A>C c.1743T>G p.N581K RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753392A>C c.1743T>G p.N581K RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753392A>C c.1743T>G p.N581K RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753392A>C c.1743T>G p.N581K RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753392A>C c.1743T>G p.N581K RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753392A>C c.1743T>G p.N581K RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries