Gene Variant Detail

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Gene BRAF
Variant P367S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF P367S does not lie within any known functional domains of the Braf protein (UniProt.org). P367S results in increased transformation ability compared to wild-type Braf in one of two cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF P367X BRAF P367S

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Transcript NM_004333.6
gDNA chr7:g.140794349G>A
cDNA c.1099C>T
Protein p.P367S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_004333 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_005250045 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_017012558 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
XM_017012559 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140794349G>A c.1099C>T p.P367S RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References