Gene Variant Detail

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Gene BRAF
Variant P731S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF P731S does not lie within any known functional domains of the Braf protein (UniProt.org). P731S results in increased transformation ability compared to wild-type Braf in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF P731S

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Transcript NM_004333.6
gDNA chr7:g.140734707G>A
cDNA c.2191C>T
Protein p.P731S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140734707G>A c.2191C>T p.P731S RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140734707G>A c.2191C>T p.P731S RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140734707G>A c.2191C>T p.P731S RefSeq GRCh38/hg38
NM_004333 chr7:g.140734707G>A c.2191C>T p.P731S RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140734707G>A c.2191C>T p.P731S RefSeq GRCh38/hg38
XM_005250045 chr7:g.140734707G>A c.2191C>T p.P731S RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References