Gene Variant Detail

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Gene BRAF
Variant Q609E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF Q609E lies within the protein kinase domain of the Braf protein (UniProt.org). Q609E results in increased transformation ability compared to wild-type Braf in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF Q609E

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Transcript NM_004333.6
gDNA chr7:g.140753310G>C
cDNA c.1825C>G
Protein p.Q609E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753310G>C c.1825C>G p.Q609E RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753310G>C c.1825C>G p.Q609E RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753310G>C c.1825C>G p.Q609E RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753310G>C c.1825C>G p.Q609E RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753310G>C c.1825C>G p.Q609E RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753310G>C c.1825C>G p.Q609E RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753310G>C c.1825C>G p.Q609E RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753310G>C c.1825C>G p.Q609E RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries