Gene Variant Detail

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Gene BRAF
Variant S607F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF S607F lies within the protein kinase domain of the Braf protein (UniProt.org). S607F demonstrates decreased transformation ability in cell culture (PMID: 29533785), however, results in Erk1/2 and Braf phosphorylation similar to wild-type Braf (PMID: 32059434), and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF S607F

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Transcript NM_004333.6
gDNA chr7:g.140753315G>A
cDNA c.1820C>T
Protein p.S607F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140753315G>A c.1820C>T p.S607F RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753315G>A c.1820C>T p.S607F RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753315G>A c.1820C>T p.S607F RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753315G>A c.1820C>T p.S607F RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753315G>A c.1820C>T p.S607F RefSeq GRCh38/hg38
NM_004333 chr7:g.140753315G>A c.1820C>T p.S607F RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753315G>A c.1820C>T p.S607F RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753315G>A c.1820C>T p.S607F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
BRAF S607F unknown