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Gene BRAF
Variant Y656D
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions BRAF Y656D lies within the protein kinase domain of the Braf protein (UniProt.org). Y656D has not been biochemically characterized, but demonstrates decreased transformation ability in cell culture (PMID: 29533785), and therefore, is predicted to lead to a loss of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF inact mut BRAF Y656D

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Transcript NM_004333.6
gDNA chr7:g.140749313A>C
cDNA c.1966T>G
Protein p.Y656D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.2 chr7:g.140749313A>C c.1966T>G p.Y656D RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140749313A>C c.1966T>G p.Y656D RefSeq GRCh38/hg38
XM_005250045 chr7:g.140749313A>C c.1966T>G p.Y656D RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140749313A>C c.1966T>G p.Y656D RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140749313A>C c.1966T>G p.Y656D RefSeq GRCh38/hg38
NM_004333 chr7:g.140749313A>C c.1966T>G p.Y656D RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140749313A>C c.1966T>G p.Y656D RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140749313A>C c.1966T>G p.Y656D RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References