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Gene BRAF
Variant T599A
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions BRAF T599A lies within the protein kinase domain of the Braf protein (UniProt.org). T599A does not result in increased MEK or ERK phosphorylation and does not transactivate CRAF (PMID: 22506009), and demonstrates decreased transformation ability compared to wild-type Braf in cell culture (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF inact mut BRAF T599A

BRAF mutant BRAF T599X BRAF T599A

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Transcript NM_004333.6
gDNA chr7:g.140753340T>C
cDNA c.1795A>G
Protein p.T599A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753340T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753340T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140749328T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753340T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140749328T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753340T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753340T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753340T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753340T>C c.1795A>G p.T599A RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753340T>C c.1795A>G p.T599A RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References