ALK L1256F
Gene Variant Detail

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Gene ALK
Variant L1256F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK L1256F lies within the protein kinase domain of the Alk protein (UniProt.org). L1256F demonstrates transforming and tumorigenic activity and confers drug resistance in the context of ALK fusions (PMID: 29650534, PMID: 30662002), but has not been individually characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK L1256F

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Transcript NM_004304.5
gDNA chr2:g.29209856G>A
cDNA c.3766C>T
Protein p.L1256F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29209856G>A c.3766C>T p.L1256F RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29209856G>A c.3766C>T p.L1256F RefSeq GRCh38/hg38
NM_004304 chr2:g.29209856G>A c.3766C>T p.L1256F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References