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Gene PIK3CA
Variant Q546R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA Q546R lies within the PIK helical domain of the Pik3ca protein (UniProt.org). Q546R results in increased cell proliferation, migration, and Akt phosphorylation (PMID: 34779417) and increased cell survival and transforming ability in culture (PMID: 26627007, PMID: 29533785, PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA Q546R

PIK3CA mutant PIK3CA exon10 PIK3CA Q546X PIK3CA Q546R

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Transcript NM_006218.4
gDNA chr3:g.179218307A>G
cDNA c.1637A>G
Protein p.Q546R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179218307A>G c.1637A>G p.Q546R RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218307A>G c.1637A>G p.Q546R RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218307A>G c.1637A>G p.Q546R RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218307A>G c.1637A>G p.Q546R RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218307A>G c.1637A>G p.Q546R RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218307A>G c.1637A>G p.Q546R RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218307A>G c.1637A>G p.Q546R RefSeq GRCh38/hg38
NM_006218 chr3:g.179218307A>G c.1637A>G p.Q546R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA Q546R prostate cancer sensitive MEN1611 Preclinical Actionable In a preclinical study, MEN1611 (CH5132799) inhibited proliferation of prostate cancer cells harboring PIK3CA Q546R in culture (PMID: 21558396). 21558396