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Gene RET
Variant E732K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET E732K lies within the protein kinase domain of the Ret protein (UniProt.org). E732K has been demonstrated to confer drug resistance in the context of KIF5B-RET in culture (PMID: 29908090), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET E732K

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Transcript NM_020975.6
gDNA chr10:g.43116641G>A
cDNA c.2194G>A
Protein p.E732K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43118411G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43118411G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43118411G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_020630 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43116641G>A c.2194G>A p.E732K RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries