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Gene | RET |
Variant | V738A |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | RET V738A lies within the protein kinase domain of the Ret protein (UniProt.org). V738A has been demonstrated to confer drug resistance in the context of KIF5B-RET in culture (PMID: 29908090, PMID: 33161056), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, May 2025). |
Associated Drug Resistance | Y |
Category Variants Paths |
RET mutant RET V738A |
Transcript | NM_020975.6 |
gDNA | chr10:g.43116660T>C |
cDNA | c.2213T>C |
Protein | p.V738A |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |