RET V738A
Gene Variant Detail

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Gene RET
Variant V738A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET V738A lies within the protein kinase domain of the Ret protein (UniProt.org). V738A has been demonstrated to confer drug resistance in the context of KIF5B-RET in culture (PMID: 29908090, PMID: 33161056), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET V738A

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Transcript NM_020975.6
gDNA chr10:g.43116660T>C
cDNA c.2213T>C
Protein p.V738A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_020630 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43116660T>C c.2213T>C p.V738A RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References