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Gene RET
Variant Y806N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET Y806N lies within the protein kinase domain of the Ret protein (UniProt.org). Y806N has been demonstrated to confer drug resistance in the context of KIF5B-RET in culture (PMID: 29908090), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET Y806N

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Transcript NM_020975.6
gDNA chr10:g.43119554T>A
cDNA c.2416T>A
Protein p.Y806N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.5 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43123723T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_020630 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43124884T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_020975 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43123723T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119554T>A c.2416T>A p.Y806N RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
RET Y806N unknown