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Gene RET
Variant F998V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET F998V lies within the protein kinase domain of the Ret protein (UniProt.org). F998V has been demonstrated to confer drug resistance in the context of KIF5B-RET in culture (PMID: 29908090), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET F998V

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Transcript NM_020975.6
gDNA chr10:g.43124935T>G
cDNA c.2992T>G
Protein p.F998V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.5 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_020630 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_020975 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43124935T>G c.2992T>G p.F998V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References