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Gene BRAF
Variant A762E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF A762E does not lie within any known functional domains of the Braf protein (UniProt.org). A762E has been demonstrated to confer secondary resistance to Egfr inhibitors in culture (PMID: 27478040), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Jul 2024).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF A762E

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Transcript NM_004333.6
gDNA chr7:g.140734613G>T
cDNA c.2285C>A
Protein p.A762E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140734613G>T c.2285C>A p.A762E RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140734613G>T c.2285C>A p.A762E RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140734613G>T c.2285C>A p.A762E RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References