Gene Variant Detail

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Gene BRAF
Variant H574N
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF H574N lies within the protein kinase domain of the Braf protein (UniProt.org). H574N results in Erk phosphorylation similar to wild-type Braf in culture (PMID: 27478040), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF H574N

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Transcript NM_004333.6
gDNA chr7:g.140754208G>T
cDNA c.1720C>A
Protein p.H574N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140754208G>T c.1720C>A p.H574N RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140754208G>T c.1720C>A p.H574N RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140753313G>T c.1720C>A p.H574N RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140754208G>T c.1720C>A p.H574N RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140754208G>T c.1720C>A p.H574N RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140754208G>T c.1720C>A p.H574N RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140754208G>T c.1720C>A p.H574N RefSeq GRCh38/hg38
NM_004333 chr7:g.140754208G>T c.1720C>A p.H574N RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140754208G>T c.1720C>A p.H574N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References