RET I852M
Gene Variant Detail

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Gene RET
Variant I852M
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET I852M lies within the protein kinase domain of the Ret protein (UniProt.org). I852M demonstrates proliferation similar to cells expressing V804M and migration ability less than cells expressing A883F, but results in constitutive activation of Ret and modest transforming ability in culture (PMID: 21711375), and therefore, is predicted to lead to a gain of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET I852M

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Transcript NM_020975.6
gDNA chr10:g.43119694C>G
cDNA c.2556C>G
Protein p.I852M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_020975 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_020630 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119694C>G c.2556C>G p.I852M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References