Gene Variant Detail

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Gene RET
Variant K907E
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions RET K907E lies within the protein kinase domain of the Ret protein (UniProt.org). K907E results in a loss of response to GDNF-regulated apoptosis (PMID: 10921886), and inhibits the function of a concurrent activating RET mutation (C634R) in culture (PMID: 9502784), and therefore, is predicted to lead to a loss of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET K907E

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Transcript NM_020975.6
gDNA chr10:g.43120192A>G
cDNA c.2719A>G
Protein p.K907E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406743.1 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_020630 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43124950A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43124950A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43124950A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_020975 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120192A>G c.2719A>G p.K907E RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References